Biomed Pharmacother. Epub Mar Berg , Calyptranthes tricona D. Legrand and Myrciaria plinioides D.
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Biomed Pharmacother. Epub Sep Neuromodulatory effects of Calyptranthes grandifolia extracts against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
Electronic address: marcia. Previous studies revealed that some natural products have neuroprotective properties, including species of the Myrtaceae family. However, the neuromodulatory potential of Calyptranthes grandifolia is not clear.
In the present study, we examined the ability of the ethanol and hexane leaf extracts of C. Initially, we investigated the potential of the extracts to inhibit the neurodegenerative-related enzymes c-Jun N-terminal kinase 3 JNK3 and acetylcholinesterase AChE. In order to verify the possible effects of both extracts on 6-OHDA-induced cell death, hydrogen peroxide generation, mitochondrial potential and caspases-3 activity were assessed.
In addition, when co-treating SH-SY5Y cells with 6-OHDA and the extracts, oxidative stress was inhibited by both extracts through a decrease of mitochondrial depolarization and caspases-3 activity. In summary, ethanol and hexane extracts of C. All rights reserved.
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A macrophage lineage was used, characterized by the release of inflammatory cytokines. The negative control There were no significant differences when treated with hexanic extract data not shown. Herath et al 42 demonstrated that different serotypes of LPS produce different responses upon cell stimulation. However, LPS significantly activated the pathway.
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