Eran considerados perturbadores endocrinos u hormonalmente activos. Su presencia es un riesgo para la salud pues afecta la homeostasis endocrina de tanto el hombre como de los animales. El DES se ha utilizado desde en las primeras semanas de embarazo hasta la semana 35 para evitar el aborto. Se puede conseguir en el mercado bajo diferentes nombres comerciales, como por ejemplo Dimeprost o antiguamente Distilbene. Resulta ser tan activo como el estradiol.
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This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. It also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth.
Definition MSH A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. Merck, 11th ed Definition CSP synthetic nonsteroidal estrogen used in the treatment of menopausal, postmenopausal, and other disorders sensitive to estrogens; an epigenetic carcinogen.
A well-known teratogen and carcinogen, DES inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
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